93 patients with mild-to-moderate knee osteoarthritis were randomized to either an 8-week neuromuscular exercise (NEMEX) program or treatment with analgesic and anti-inflammatory drugs (PHARMA). Patients were assessed after 2 and 12 months for results on the Knee Injury and Osteoarthritis Index Score (KOOS). Primary outcome was the KOOS ADL scale, which demonstrated no significant difference between groups for change from baseline after 2 or 12 months. The KOOS Symptoms scale demonstrated significantly greater improvement from baseline after 12 months in the NEMEX group compared to the PHARMA group.