163 patients scheduled for total knee arthroplasty were randomized to an analgesic regimen which included either an adductor canal block alone, periarticular infiltration analgesia alone, or combined adductor canal block and periarticular infiltration analgesia. Patients were assessed for pain scores and opioid consumption over the first 3 days postoperatively. For pain score, significant differences were observed between the ACB+PAI group and the ACB alone group, with significantly lower levels in the ACB+PAI group on postoperative days (POD) 1 and 3. For opioid consumption, significant differences were observed for both the ACB+PAI group and PAI alone group compared to the ACB alone group, with significantly reduced opioid consumption on POD2 and 3 in the ACB+PAI group and the PAI alone group.