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ARTHROPLASTY
IORA prophylaxis achieves greater vancomycin tissue concentration vs IV administration in TKA
J Arthroplasty. 2018 Jul;33(7S):S13-S18. doi: 10.1016/j.arth.2018.03.013
Contributing Authors

SW Young M Zhang GA Moore MJ Spangehl HD Clarke SJ Chin

22 patients with a BMI over 35 and scheduled for total knee arthroplasty were randomized to either intraosseous regional administration (IORA) vancomycin 500mg or intravenous vancomycin 15mg/kg. Intraoperative samples of subcutaneous fat and femoral bone were obtained and tested for concentrations of vancomycin. Results demonstrated significantly greater concentrations of vancomycin in the IORA group compared to the IV group in both subcutaneous fat samples and femoral bone samples.

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OrthoEvidence. IORA prophylaxis achieves greater vancomycin tissue concentration vs IV administration in TKA. ACE Report. 2018;8(8):12. Available from: https://myorthoevidence.com/AceReport/Report/

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