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Previous Ace Report OTA2018: Antiosteoporosis supplements demonstrate improved outcome after proximal humerus fixation Next Ace Report OTA2018: Similar efficacy and safety of LMWH 30mg BID and aspirin 81mg BID for VTE prophylaxis
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OTA2018: Equivalence not demonstrated, higher union with ICBG vs. rhBMP-2 for open tibial fracture
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OTA2018: Equivalence not demonstrated, higher union with ICBG vs. rhBMP-2 for open tibial fracture

Contributing Authors

Paul Tornetta W Obremskey L Cannada L Reider J Luly E MacKenzie

23 patients with an open midshaft tibial fracture fixed with an intramedullary nail were randomized to grafting using a recombinant human morphogenetic protein (rhBMP)-2 supplemented allograft or an autologous iliac crest bone graft (ICBG). Equivalence of rhBMP-2 to ICBG was tested for radiographic union rate, using an equivalence margin of -20% to +20%. Comparison of groups could not conclude equivalence of rhBMP-2 to ICBG, with union rates within 52 weeks of 58.3% and 81.8% in the groups, respectively.

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OrthoEvidence. OTA2018: Equivalence not demonstrated, higher union with ICBG vs. rhBMP-2 for open tibial fracture. ACE Report. 2018;8(10):73. Available from: https://myorthoevidence.com/AceReport/Report/

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