9 studies were included in this meta-analysis comparing computer-navigated and conventional TKA with regards to radiological, long-term function and survivorship outcomes. Outcomes of interest included the outlier rate of coronal and sagittal alignment of the femoral and tibial components, the outlier rate of lower extremity alignment, range of motion, the Knee Society Score (KSS), the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index, revision rate and rate of aseptic loosening. Results found significantly lower outlier rates of sagittal alignment of the femoral component and coronal alignment of the tibial component in the computer-navigated TKA group compared to the conventional TKA group. No significant differences were observed between the two groups in all remaining outcomes.