Platelet-rich plasma (PRP) has gained prominence in recent years due to its potential regenerative and anti-inflammatory properties. Evidence on its efficacy has been mixed to date, though it has shown some promise in knee osteoarthritis. There is uncertainty in terms of the frequency and number of injections that provide optimal outcomes. In this study, the authors assessed randomized controlled trials comparing single to multiple PRP injections at 6-12 months in terms of pain and function improvements. Based on their meta-analysis, they found that multiple injections outperformed single injections in terms of function, but there was no difference in terms of pain.