Eight hundred and thirteen patients scheduled for a total knee arthroplasty were randomized to receive a single post-operative dose of osocimab (0.3, 0.6, 1.2, 1.8mg/kg) or a pre-operative dose of osocimab (0.3, 1.8mg/kg) for the reduction of thromboembolic events, compared to enoxaparin or apixaban. The primary time-point was at the time of venography (approximately 10-13 days post-operation). Results revealed post-operative doses of osocimab 0.6mg/kg or higher to be non-inferior to enoxaparin for the primary outcome of composite venous thromboembolism at 10-13 days post-operation. The pre-operative 1.8mg/kg dose of osocimab was found to be superior to enoxaparin for the primary outcome.