Forty-nine knees with Osgood-Schlatter disease were randomized to receive three monthly injections of dextrose or normal saline for the improvement anterior knee pain. The outcome of interest was anterior knee pain, as measured on the Victorian Institute of Sport Assessment (VISA) score. Follow up occurred one, two and three months after the first injection took place. Results of the study revealed no significant differences in VISA scores between the dextrose group and normal saline group. Both groups reported significant improvements from baseline at all follow-up time-points.