
Osteoarthritis
Efficacy and Safety of Repeated Courses of Hyaluronic Acid Injections for Knee Osteoarthritis
Semin Arthritis Rheum. 2018;48(2):168-75
Seven RCTs and 10 cohort studies with intra-articular hyaluronic acid (IA-HA) as the primary treatment option, at least one repeat course of IA-HA and that included knee pain as an outcome were included in this systematic review. The primary outcome was the reduction in knee pain. Secondary outcomes included the number of treatment-related adverse events (AEs) and serious treatment-related adverse events (SESs).
Unlock the full article
Get unlimited access to OrthoEvidence with a free trial
Start TrialCritical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or continue reading this full article
Register Now

Subscribe to "The Pulse"
Evidence-Based Orthopaedics direct to your inbox.