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Osteoarthritis
The Impact of Excluding Patients with End-Stage Knee Disease in Hyaluronic Acid Trials

Advances in Therapy. 2018;36:147-61

Contributing Authors

M Nicholls Nicholls M. Shaw P. Niazi F. Bhandari M. Bedi A.

Twenty RCT’s that compared intra-articular hyaluronic injections (IA-HA) with saline injections in patients whose osteoarthritis (OA) severity was diagnosed using the K-L grade were included in this meta-analysis. The primary outcome was mean change in pain from baseline to early (4-13 weeks) and late (22-27 weeks) follow-up visits for two subgroups: early-moderate OA and late OA. Safety was also evaluated based on the number of treatment related adverse events.

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OrthoEvidence. The Impact of Excluding Patients with End-Stage Knee Disease in Hyaluronic Acid Trials. ACE Report. 2020;():. Available from: https://myorthoevidence.com/AceReport/Report/

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