100 patients undergoing total knee arthroplasty (TKA) were randomized to undergo drainage-clamping with either tranexamic acid and carbazovhrome sodium sulfonate hydrate, or saline control to assess the risk associated with post-operative hemostasis. The post-operative drained blood was significantly reduced in the intervention group,when compared to the controls. This finding was accompanied with a similar occurrence of deep vein thrombosis (DVT), indicating that the intervention group was at a similar risk of DVT complication while reducing blood loss.