This network meta-analysis identified 6 Cochrane Collaboration systematic reviews, comprised in total of 31 studies. These reviews examined the safety and benefits of 6 biologics in patients with rheumatoid arthritis (abatacept, adalimumab, anakinra, etanercept, infliximab and rituximab). The primary outcomes of this study were safety (number of withdrawals related to adverse effects) and benefit (50% improvement in reported criteria of the American College of Rheumatology [ACR50]). The biologics adalimumab and etanercept were most effective, with etanercept showing greater safety compared to the other biologics. Results of this analysis were limited by the heterogeneous population characteristics and indirect comparisons between trials.