ARTHROPLASTY
Metal-on-metal THA increases HLA DR+CD8+ T-cells & correlates with immunological reactions
Acta Orthop. 2011 Feb;82(1):6-12. Epub 2010 Dec 2985 patients undergoing total hip arthroplasty (THA) were randomized to receive either a metal-on-metal bearing or a metal-on-polyethylene prosthesis. The primary outcome was elevation of circulating HLA DR+ CD8+ T-cells and correlation with chromium and cobalt concentrations. Results indicated that metal-on-metal THA increased chromium and cobalt concentrations which resulted in a correlation in immunological reactions. This was associated with the increase in HLA DR+CD8+ T-cells and a decrease in B-cells.
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