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Previous Ace Report Circular fixator application for bicondylar tibial plateau fractures reduces hospital stay Next Ace Report Circular fixator application for bicondylar tibial plateau fractures reduces hospital stay
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Trauma
Discontinuing alendronate after 5 years of treatment, does it affect fracture risk?
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Trauma
Discontinuing alendronate after 5 years of treatment, does it affect fracture risk?
JAMA. 2006 Dec 27;296(24):2927-38.
Contributing Authors

Dennis M Black Ann V Schwartz Kristine E Ensrud Jane A Cauley Silvina Levis Sara A Quandt Suzanne Satterfield Robert B Wallace Douglas C Bauer Lisa Palermo Lois E Wehren Antonio Lombardi Arthur C Santora Steven R Cummings

1099 postmenopausal women randomized to receive alendronate in FIT and underwent 5 years of prior alendronate treatment were further randomized to receive 5 mg or 10 mg of alendronate, or a placebo for 5 years. The results of the study revealed that women who had discontinued alendronate treatment after 5 years experienced a moderate decline in bone mineral density and a moderate rise in biochemical markers, but did not experience a rise in fracture risk other than for clinical vertebral fractures.

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OrthoEvidence. Discontinuing alendronate after 5 years of treatment, does it affect fracture risk?. ACE Report. 2015;5(2):11. Available from: https://myorthoevidence.com/AceReport/Report/

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