60 male ASA I–II patients undergoing arthroscopic ACL reconstruction were included in this study to compare different postoperative analgesics. Patients were randomized to receive 10 mg morphine and 0.5% bupivacaine, 100 mg tramadol and 0.5% bupivacaine, or 20 ml isotonic saline. The results of this study indicated that intra-articular morphine and bupivacaine provide better pain relief, longer analgesic duration (time until first request for analgesics), less analgesic requirement, and shorter unassisted ambulation and discharge time compared to intra-articular tramadol and bupivacaine.