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Previous Ace Report Orthotic use provides promising outcomes for patients with tibiofemoral osteoarthritis Next Ace Report Orthotic use provides promising outcomes for patients with tibiofemoral osteoarthritis
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Metabolic Disorders
Denosumab increases bone mineral density in male patients with low BMD
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Metabolic Disorders
Denosumab increases bone mineral density in male patients with low BMD
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This report has been verified by one or more authors of the original publication.
J Clin Endocrinol Metab. 2012 Sep;97(9):3161-9. doi: 10.1210/jc.2012-1569. Epub 2012 Jun 21
Contributing Authors

E Orwoll CS Teglbjærg BL Langdahl R Chapurlat E Czerwinski DL Kendler JY Reginster A Kivitz EM Lewiecki PD Miller MA Bolognese MR McClung HG Bone Ö Ljunggren B Abrahamsen U Gruntmanis YC Yang RB Wagman S Siddhanti A Grauer JW Hall Boo

242 male patients with low bone mineral density were randomized to receive treatment with denosumab or a placebo to determine the effect of denosumab on bone mineral density in the male population. After 1 year of treatment, the denosumab group demonstrated a significantly greater increase in bone mineral density than the control group at the lumbar spine, total hip, femoral neck, trochanter, and the one third radius. There was also a significant decrease in serum CTX levels in the denosumab group at 15 days. The two groups did not differ significantly with respect to adverse events.

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OrthoEvidence. Denosumab increases bone mineral density in male patients with low BMD. ACE Report. 2013;3(5):144. Available from: https://myorthoevidence.com/AceReport/Report/

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