80 patients who required treatment for mechanical neck pain were randomized to receive conventional cervical thrust manipulation or Kinesio Taping to determine their effects on short-term pain, disability, and cervical range of motion (CROM). Numeric pain rating scale (NPRS), Neck Disability Index (NDI), and goniometric CROM analysis were assessed one week postintervention. The results indicated both groups illustrated improvements in pain; however improvements of disability were not above the criteria for minimal clinically important difference. Furthermore, there were no clinically relevant differences between groups.