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AAOS: Topical tranexamic acid effacacious method for blood loss management in TKA

73 patients scheduled for total knee arthroplasty were randomized to determine the efficacy of topical tranexmic acid for the management of perioperative blood loss. Patients received a topical administration of either 2.0g of tranexmic acid in 75mL of saline, or 75mL of saline alone. Perioperative results indicated that patients who were treated with tranexamic acid experienced significantly lower blood loss, higher postoperative hemoglobin levels, and lower hemoglobin loss. There was no difference between the two groups in venous thromboembolism rate.

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  • Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
  • Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
  • Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
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OrthoEvidence. AAOS: Topical tranexamic acid effacacious method for blood loss management in TKA. ACE Report. 2013;3(3):296. Available from: https://myorthoevidence.com/AceReport/Report/

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