98 patients with acetabular fractures who underwent surgical fixation were randomized into four groups to determine the abundance of heterotopic ossification, non-union, and differences in pain and function with varying durations of indomethacin treatment. The first Group consisted of a placebo for 6 weeks, group 2 consisted of 3 days of indomethacin followed by placebo for a total of 6 weeks, group 3 consisted of 1 week of indomethacin followed by 5 weeks of placebo, and group 4 consisted of 6 weeks of indomethacin treatment. After 1 year of evaluation, indomethacin did not affect the incidence or volume of clinically significant heterotopic ossification and increased the symptomatic non-union of posterior wall according to VAS pain and CT scans.