269 patients were randomized to determine the efficacy and safety of cervical arthroplasty with the Kineflex|C artificial disc in treatment of cervical radiculopathy. Patients were allocated to receive either cervical total disc replacement with the Kineflex|C cervical disc or anterior cervical discectomy and fusion, and were followed-up for a minimum of 24 months. Results at 24 month follow-up indicated that clinical success, range of motion, and status of adjacent-level deterioration were all improved in the Kineflex|C group compared to ACDF. Clinical outcomes assessing pain and disability were similar between treatments. Reoperation rates were similar between groups.