
Osteoarthritis
Zaltoprofen is noninferior to diclofenac for the treatment of knee OA
Expert Opin Pharmacother. 2011 May;12(7):1007-15. doi: 10.1517/14656566.2011.566867. Epub 2011 Apr 7This study evaluated whether zaltoprofen was as a noninferior alternative (in regards to safety and efficacy) to diclofenac for the treatment of knee osteoarthritis (OA). 213 patients were randomized to either zaltoprofen (80 mg t.i.d.) or diclofenac (50 mg t.i.d.) and were assessed after 4 weeks. Results indicated that both groups experienced significant (but comparable) improvement in pain intensity, functional status, and pain relief when compared to baseline values. Moreover, no serious adverse events were observed with either medication.
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