SPINE
ISASS: Use of rhBMP-2 and autologous bone in PLIF display similar clinical outcomes
40 patients undergoing posterior lumbar interbody fusion (PLIF) were randomized to receive polyetheretherketone (PEEK) cages filled with either recombinant human bone morphogenic protein (rhBMP-2) or autologous bone to compare their clinical and radiological effects. At 24 months, the incidence of end plate resorption, osteolysis, and ectopic bone formation were frequently observed with rhBMP-2; however, this did not result in any clinical differences when compared with autologous bone.
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