10 studies (randomized controlled trials (RCT) or quasi-RCTs) were included in this analysis which evaluated the use of plating and intramedullary nailing as a method of fixation in humeral shaft fractures. Overall, 439 patients were assessed all together in the included studies, with data available on nonunion, delayed union, postoperative infection, and reoperation rates at a minimum of 12 months postsurgically. Pooled results indicated that similar incidence of nonunion, delayed union and infection occurred between treatment methods. While initially reoperation rates were better with the use of plating, a sensitivity analysis found no difference between methods. Postoperative shoulder complications were less frequent with plate fixation.