39 patients with a lesion of the supraspinatus tendon were randomized to receive either platelet-rich plasma (PRP) injections or dry needling to determine the comparative efficacy of the treatments for rotator cuff pathology. Follow-up was conducted for 6 months following the second injection, which took place 4 weeks after the first injection. Analysis at final follow-up indicated that total score on the Shoulder Pain and Disability Index was significantly better in the PRP group; however significance did not remain when pain and disability subscales were assessed individually. Improvement in range of motion was consistently higher at 3 and 6 months in the PRP group, and reached significance in forward flexion and internal rotation.