330 patients with anterior cruciate ligament deficiency were randomized to undergo ACL reconstruction with one of the following three techniques: anatomic patellar tendon, anatomic quadruple-stranded hamstring tendon, or anatomic double-bundle using hamstring tendons. Patients were followed up for a minimum of 2 years, primarily observing disease-specific quality of life. At final follow-up, there was no difference between groups for disease-specific quality of life, although reconstruction with patellar tendons was associated with less knee laxity and a lower number of traumatic re-ruptures. There were no significant differences in any other outcome measured.