330 patients were randomized to undergo anterior cruciate ligament (ACL) reconstruction with either a patellar tendon (PT), a quadruple-stranded hamstring (HT), or a double-bundle hamstring (DB) autograft, to compare incidence of post-operative adverse effects between surgical methods. Following assessments over a 2 year period, results indicated that 13% of patients repeat surgery. Repeat surgery was required in 8.2%, 17.3% and 14.5% of the patients with PT, HT and DB procedures respectively.Patients with HT and DB autografts experienced more hamstring injuries compared to the PT group. However, the PT group had a higher incidence of kneeling pain, compared to the other two groups.