30 patients undergoing single-bundle anterior cruciate ligament (ACL) reconstruction with hamstring grafts were randomized to receive either the transtibial or anteromedial portal technique. The purpose was to determine the difference between the two techniques in bone tunnel placement, graft angle and bending of the graft angle at the tunnel aperture. Seven days following surgery, results indicated that the anteromedial technique resulted in closer placement of bone tunnels to the anatomical footprint, and resulted in graft obliquity that was closer to the native ACL.