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Mitomycin C effects on epidural fibrosis in microendoscopic discectomy
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Mitomycin C effects on epidural fibrosis in microendoscopic discectomy
J Neurosurg Spine. 2013 May;18(5):421-7. doi: 10.3171/2013.1.SPINE12564. Epub 2013 Mar 8
Contributing Authors

L Liu T Sui X Hong X Wu X Cao

75 patients undergoing single level unilateral microendoscopic discectomy for lumbar disc herniation were randomized to either receive a cotton wool impregnated with 0.5mg/ml of mitomycin C (MMC) or saline at the surgical site for discectomy. The 6 month results, studying the effects of MMC on preventing epidural fibrosis, showed no differences in clinical and neurological assessments between the two groups. Radiographic evaluations, however, according to Ross Grading and modified grading system indicated decreased epidural fibrosis with MMC.

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OrthoEvidence. Mitomycin C effects on epidural fibrosis in microendoscopic discectomy. ACE Report. 2013;3(8):607. Available from: https://myorthoevidence.com/AceReport/Report/

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