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Previous Ace Report Interval-compressed chemotherapy effective in treatment of localized Ewing sarcoma Next Ace Report Interval-compressed chemotherapy effective in treatment of localized Ewing sarcoma
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Ifosfamide not necessary in chemotherapy for nonmetastatic osteosarcoma
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Ifosfamide not necessary in chemotherapy for nonmetastatic osteosarcoma
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This report has been verified by one or more authors of the original publication.
J Clin Oncol. 2012 Jun 10;30(17):2112-8. doi: 10.1200/JCO.2011.38.4420. Epub 2012 May 7
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S Ferrari P Ruggieri G Cefalo A Tamburini R Capanna F Fagioli A Comandone R Bertulli G Bisogno E Palmerini M Alberghini A Parafioriti A Linari P Picci G Bacci

246 patients with nonmetastatic osteosarcoma were randomized to evaluate the addition of ifosfamide to a primary chemotherapy regimen of methotrexate, cisplatin, and doxorubicin, with patients allocated to chemotherapy with or without ifosfamide. After a median follow-up of 76 months, there was no difference between groups in overall survival, event-free survival, and the percentage of patients with a good response to primary chemotherapy. Moreover, those treated with ifosfamide displayed significantly greater hematologic toxicity.

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OrthoEvidence. Ifosfamide not necessary in chemotherapy for nonmetastatic osteosarcoma. ACE Report. 2013;3(8):609. Available from: https://myorthoevidence.com/AceReport/Report/

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