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Previous Ace Report Ifosfamide not necessary in chemotherapy for nonmetastatic osteosarcoma Next Ace Report Ifosfamide not necessary in chemotherapy for nonmetastatic osteosarcoma
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Ewing sarcoma: Similar survival rates with intensified dose regimen of VDC/IE
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Ewing sarcoma: Similar survival rates with intensified dose regimen of VDC/IE
J Clin Oncol. 2009 May 20;27(15):2536-41. doi: 10.1200/JCO.2008.19.1478. Epub 2009 Apr 6
Contributing Authors

L Granowetter R Womer M Devidas M Krailo C Wang M Bernstein N Marina P Leavey M Gebhardt J Healey RC Shamberger A Goorin J Miser J Meyer CA Arndt S Sailer K Marcus E Perlman P Dickman HE Grier

478 patients under the age of 30, diagnosed with non-metastatic ESFT (or the Ewing sarcoma family of tumours), were randomized to either a standard or intensified dose regimen of vincristine, doxorubicin, and cyclophosphamide (VDC) along with ifosfamide and etoposide (IE) to assess the 5-year event-free and overall survival rates between groups. Results indicated that there was no significant difference between groups in the 5-year event-free and overall survival rates or the incidence of secondary leukemia. However, the frequency of solid secondary tumours was higher in the intensified group, and half of these cases had not been treated with radiation.

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OrthoEvidence. Ewing sarcoma: Similar survival rates with intensified dose regimen of VDC/IE. ACE Report. 2013;3(8):611. Available from: https://myorthoevidence.com/AceReport/Report/

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