42 patients undergoing cruciate-retaining cemented total knee replacement were randomized to compare the feasibility, patient satisfaction and functional outcomes between the OtisMed system of custom cutting blocks 3D reconstruction and standard computer navigation. 6 month results, measured by EQ-5D scores, Oxford Knee scores, satisfaction, pain, and range of motion, indicated no differences between the two procedures. The custom cutting system resulted in fewer ligament releases. On-site inter-departmental collaboration, as well as collaboration with the manufacturer would be necessary to bring about standard use of the OtisMed system in a hospital setting.