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Osteogenic protein-1 is safe and effective in the treatment of tibial nonunion
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Osteogenic protein-1 is safe and effective in the treatment of tibial nonunion
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J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 2):S151-8

122 patients with 124 tibial nonunions were treated with intramedullary nailing and randomized to receive a fresh bone autograft or recombinant human osteogenic protein-1 (rhOP-1). Patients were assessed for severity of pain at the fracture site, the ability to walk with full weightbearing, need for surgical re-treatment of the nonunion, radiographic evaluation of healing, and physician satisfaction with the clinical course. Clinical and radiographic judgments of healing were not significantly different between the two groups through 2 years.

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OrthoEvidence. Osteogenic protein-1 is safe and effective in the treatment of tibial nonunion. ACE Report. 2014;4(8):13. Available from: https://myorthoevidence.com/AceReport/Report/

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