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Ankle arthrodesis: rhPDGF-BB/TCP is an effective and safe alternative to autograft
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Foot & Ankle
Ankle arthrodesis: rhPDGF-BB/TCP is an effective and safe alternative to autograft
J Bone Joint Surg Am. 2013 Jul 3;95(13):1184-92. doi: 10.2106/JBJS.K.01422

Four hundred and thirty four patients in need of either an ankle or hindfoot arthrodesis were randomized to undergo the procedure using either the recombinant human (rh) PDGF-BB/TCP or autograft as bone fusion promoters to determine the non-inferiority of rhPDGF-BB/TCP. Results indicated that rhPDGF-BB/TCP proved to be non-inferior to autograft with respect to fusion rates, clinical union, radiographic union, pain, quality of life, and functional outcomes. Furthermore, rhPDGF-BB/TCP was equally, if not more, safe compared to autograft, with no significant differences between the two groups in terms of complications and adverse events.

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OrthoEvidence. Ankle arthrodesis: rhPDGF-BB/TCP is an effective and safe alternative to autograft. ACE Report. 2013;3(10):3. Available from: https://myorthoevidence.com/AceReport/Report/

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