PEDIATRIC ORTHOPAEDICS
Oral alendronate cannot yet be recommended for children with OI
This report has been verified
by one or more authors of the
original publication.
J Clin Endocrinol Metab. 2011 Feb;96(2):355-64
139 children and adolescents with moderate to severe osteogenesis imperfecta (OI) were randomized to evaluate the safety and efficacy of oral alendronate (ALN). The trial primarily focused on the assessment of lumbar spine bone mineral density (LS BMD) alongside several secondary critera/data: clinical, radiological, biochemical, and multiple bone-related measurements and fracture details. Results demonstrated that ALN, compared to a placebo, effectively increased LS areal BMD z-scores, was adequately tolerated, and efficiently inhibited the activity of bone absorption. However, limited effect of ALN was observed in clinical parameters.
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