ARTHROPLASTY
Apixaban reduces major bleeding and is non-inferior when compared to enoxaparin for TKA
Thromb Haemost. 2011 Feb;105(2):245-53Data from 3 randomized-controlled trials (7337 individuals) was analyzed to evaluate the efficacy of apixaban in the treatment of TKA complications of venous thromboemolisms (VTE) including deep-vein thrombosis (DVT) and pulmonary embolism (PE), when compared against enoxaparin. Complication incidence was analyzed, along with safety endpoints. The results of the meta-analysis demonstrated that apixaban performed comparably to enoxaparin with advantages in DVT incidence and reduction of major-bleeding.
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