81 patients with a trauma related fracture underwent surgery and were administered adjunct pregabalin or a placebo to determine if pregabalin administration was an effective pain management strategy. Patients were randomized into three groups to receive low or high doses of pregabalin (75 or 150 mg) or a placebo twice a day for the duration of hospitalization. The results suggest a trend towards less required rescue medication in patients who were administered 75 mg of pregabalin; however, a post hoc calculation revealed a need for a larger sample size to validate this finding. Higher doses of pregabalin resulted in higher pain at rest and with activity.
Unlock the full ACE Report
You have access to {0} free articles per month.Click below to unlock and view this {1}
Unlock NowCritical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidence content for just $1.99 per week.
Already have an account? Log in
Subscribe to "The Pulse"
Evidence-Based Orthopaedics direct to your inbox.
{0} of {1} free articles
Become an OrthoEvidence Premium Member. Expand your perspective with high-quality evidence.
Upgrade Now
