172 patients who were scheduled for elective primary total knee arthroplasty were randomly assigned into 1 of 4 groups, 2 fibrin glue groups (Blood and Tissue Bank of Batalonia fibrin glue, and Tissucol Duo) 1 tranexamic acid group, and 1 control (receiving routine hemostasis), to determine if fibrin glue or tranexamic acid significantly reduces blood loss following TKA when compared to routine hemostasis treatment, 120 hours after treatment. The results of the study indicated that neither type of fibrin glue used in the study was more effective than routine hemostasis at reducing postoperative bleeding and transfusions; however, it does support current evidence in finding that intravenous tranexamic acid decreases postoperative blood loss.