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Intramedullary nailing of closed tibial fracture: rhBMP2-CPM augmentation not recommended
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This report has been verified by one or more authors of the original publication.
J Bone Joint Surg Am. 2013 Dec 4;95(23):2088-96. doi: 10.2106/JBJS.L.01545
Contributing Authors

T Lyon W Scheele M Bhandari KJ Koval EG Sanchez J Christensen A Valentin F Huard

387 patients with closed tibial fractures were randomized in this study to investigate the efficacy and safety of the local application of recombinant human bone morphogenetic protein 2 (rhBMP-2) within a calcium phosphate matrix (CPM) in the treatment of closed tibial fractures. Participants were subject to intramedullary nail fixation in 1 of 4 treatment protocols: 1) nail fixation alone (standard of care), 2) augmented with 1.0mg/mL rhBMP-2/CPM, 3) augmented with 2.0mg/mL rhBMP-2/CPM, or 4) augmented with buffer/CPM. The study was terminated early due to futility, with a lack of efficacy in time to fracture union.

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OrthoEvidence. Intramedullary nailing of closed tibial fracture: rhBMP2-CPM augmentation not recommended. ACE Report. 2014;4(4):18. Available from: https://myorthoevidence.com/AceReport/Report/

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