METABOLIC DISORDERS
WCO-IOF: Changes with QCT, DXA, and TBS between denosumab, alendronate, & placebo
215 postmenopausal women with low spine or total hip bone mineral density (BMD) were randomized to treatment with either denosumab, alendronate, or placebo for a period of 12 months. Quantitative computed tomography (QCT) and densitometry (DXA), in addition to a novel trabecular bone score (TBS) were evaluated to determine if a differences exists between the information provided by these three measurement tools. Results indicated that TBS significantly improved with denosumab, whereas they remained similar with alendronate and decreased with placebo. Baseline TBS was also observed to correlate with volumetric bone mineral density.
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