ARTHROPLASTY
EFORT: Intraossesous regional vancomycin effective for antibiotic tissue levels in TKA
30 patients undergoing total knee arthroplasty were randomized to one of three groups for antibiotic prophylaxis: 1g intravenous (IV) vancomycin, 250mg intraosseous regional administration (IORA) vancomycin, and 500mg IORA vancomycin. Subcutaneous fat and femoral bone samples were collected throughout the procedure and assessed for antibiotic concentration. The results demonstrated significantly higher concentrations of vancomycin in tissue samples in the two intraosseous vancomycin groups (both 250mg and 500mg) when compared to the 1g IV vancomycin group.
Unlock the full ACE Report
You have access to {0} free articles per month.Click below to unlock and view this {1}
Unlock NowCritical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidence content for just $1.99 per week.
Already have an account? Log in
Subscribe to "The Pulse"
Evidence-Based Orthopaedics direct to your inbox.
{0} of {1} free articles
Become an OrthoEvidence Premium Member. Expand your perspective with high-quality evidence.
Upgrade Now
