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Previous Ace Report No significant differences in pain and function in TKA with & without patellar resurfacing Next Ace Report No significant differences in pain and function in TKA with & without patellar resurfacing
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Osteoarthritis
Flavonoid supplement UP446 has significant symptomatic relief of knee osteoarthritis
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Osteoarthritis
Flavonoid supplement UP446 has significant symptomatic relief of knee osteoarthritis
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This report has been verified by one or more authors of the original publication.
J Med Food. 2014 Jun;17(6):707-13
Contributing Authors

BH Arjmandi LT Ormsbee ML Elam SC Campbell N Rahnama ME Payton K Brummel-Smith BP Daggy

79 patients with mild-moderate knee osteoarthritis were included in this study. Patients were randomized to treatment with either UP446 500mg/day (S. baicalensis and A. catechu compound) or control naproxen sodium 440mg/day. The purpose was to investigate the effect of UP446 500mg/day on short-term outcome in comparison to an established conservative OA treatment. Over 1 week, pain and stiffness significantly reduced in patients treated with UP446. Further long-term placebo controlled assessments are required to determine the efficacy of this supplementation.

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OrthoEvidence. Flavonoid supplement UP446 has significant symptomatic relief of knee osteoarthritis. ACE Report. 2014;4(9):47. Available from: https://myorthoevidence.com/AceReport/Report/

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