151 patients who underwent open reduction and internal fixation (ORIF) for a hip, pelvis, or acetabular fracture were randomly assigned to receive negative-pressure wound therapy (NPWT) or standard gauze dressing over the closed incisions. Postoperative surgical wound drainage, risk of infections, and hospital duration were assessed. Findings revealed that, contrary to previously published literature, NPWT reported a greater, but nonsignificant, risk of deep infection than standard gauze dressing. All deep infections occurred in patients who suffered from an acetabular fracture.