108 patients undergoing unilateral primary total knee arthroplasty were randomly allocated to either receive a thrombin-based topical hemostatic matrix or to a control group who did not receive the hemostatic agent. The study sought to determine the effects of the hemostatic sealant on inblood loss, as well as the need for transfusion. Results revealed the mean blood loss, drain output and length of stay were significantly favored the hemostatic matrix group over the control group. There was no significant difference found in transfusion requirements and mean hemoglobin loss between groups.