9 adult patients (18 ankles) with hemophilic arthropathy of the ankle were randomized to undergo a mobilization or manual therapy regimen for 6 weeks in this quasi-experimental pilot study. The intent of this study was to determine the effectiveness and safety of both physiotherapy interventions. Both therapies improved all ankle movements from pre- to post-treatment. The mobilizations group significantly improved perceived pain and quality of life from pre-to post-treatment, while both groups improved pain from post-treatment to 6 month follow-up. No patient suffered ankle haemarthrosis throughout the study period.