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Previous Ace Report Clinical events committee: an effective tool in reducing bias in industry-funded studies Next Ace Report Clinical events committee: an effective tool in reducing bias in industry-funded studies
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General Orthopaedics
Reduction of factor XI levels in TKA patients safe and effective for VTE prevention
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General Orthopaedics
Reduction of factor XI levels in TKA patients safe and effective for VTE prevention
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This report has been verified by one or more authors of the original publication.
N Engl J Med. 2015 Jan 15;372(3):232-40.
Contributing Authors

HR Büller C Bethune S Bhanot D Gailani BP Monia GE Raskob A Segers P Verhamme JI Weitz FXI-ASO TKA Investigators

300 patients scheduled for total knee arthroplasty (TKA) were randomized to receive Factor XI Antisense Oligonucleotide (FXI-ASO) 200 mg, FXI-ASO 300 mg, or enoxaparin 40 mg. This was done to evaluate the safety and efficacy of FXI-ASO in the reduction of risk of venous thromboembolism (VTE) in patients following surgery. Patient outcomes were measured through venography at day 10 +/- 2, to determine the presence of VTE, and through the occurrence of clinically relevant bleeding. Results indicated that patients taking a high dose of FXI-ASO had a decreased incidence of VTE, as well as a decrease in bleeding events following TKA, when compared to patients taking enoxaparin.

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OrthoEvidence. Reduction of factor XI levels in TKA patients safe and effective for VTE prevention. ACE Report. 2015;5(4):59. Available from: https://myorthoevidence.com/AceReport/Report/

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