Fifty two patients with chronic ankle instability were randomized to one of three groups, weight-bearing mobilization with movement (WB-MWM), high velocity and low amplitude manipulation (HVLA) of the talocrural joint, or a placebo group. The purpose of the study was to compare the two manual therapy techniques with respect to ankle dorsiflexion improvement immediately following treatment, and at several time points up to 48 hours. Both WB-MWM and HVLA groups indicated significant improvements over time and when compared to the control group, but no significant difference was observed between the two manual therapy groups.