Forty-seven patients scheduled for unicompartmental knee arthroplasty (UKA) with an Oxford implant were randomized to either cemented or cementless fixation. The purpose of this study was to evaluate whether fixation types differed with respect to radiostereometric migration. Follow-up was performed at 3, 6, 12, and 24 months postoperatively. The only consistent difference that was noted between groups was y-axis translation, with significant greater subsidence found in cementless components, mostly occurring within the first 3 months after surgery. A higher incidence in radiolucency around the tibial component was found in the cemented group compared to the cementless group.