ARTHROPLASTY
Intravenous and topical tranexamic acid have similar efficacy in TKA
Arch Orthop Trauma Surg. 2015 Apr;135(4):573-88.31 randomized controlled trials were included in this meta-analysis which was conducted with the intention of comparing systemic (intravenous (IV)) and topical (intra-articular (IA)) administration of tranexamic acid (TXA). Outcomes of interest included total blood loss, rates of transfusion, and incidence of thromboembolic events. Upon analysis of the data, it was found that there was no significant difference between the intravenous and topical application of TXA, and both were superior to the control. Furthermore, neither method of TXA application was associated with an increase in thromboembolic complications when compared to the control.
Unlock the full ACE Report
You have access to {0} free articles per month.Click below to unlock and view this {1}
Unlock NowCritical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidence content for just $1.99 per week.
Already have an account? Log in
Subscribe to "The Pulse"
Evidence-Based Orthopaedics direct to your inbox.
{0} of {1} free articles
Become an OrthoEvidence Premium Member. Expand your perspective with high-quality evidence.
Upgrade Now
