120 patients with displaced midshaft clavicular fracture were randomized to receive either open reduction and internal plate fixation, or intramedullary nailing. The purpose of this study was to determine and compare short- and midterm functional results and complication rates between fixation methods. In the short term (<6 months), less disability cumulatively was observed for the plate fixation group compared to the nail group, as evaluated by area under the curve (AUC) for the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire between 6 weeks and 6 months. Nevertheless, mean DASH scores at 6 months did not significantly differ between groups. There was no significant difference in complication rates.