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COA 2015: No high-level evidence support for postoperative antibiotic prophylaxis in TJA

26 randomized controlled trials were included in this systematic review to determine the efficacy of postoperative antibiotic prophylaxis following total knee or hip arthroplasty. This review also looked to also assess the current recommendations by orthopaedic associations on the topic of postoperative antibiotic administration. Evidence from included trials supported the use of perioperative antibiotics, but not postoperative administration. Current recommendations by the American Academy of Orthopaedic Surgeons (AAOS), the British Orthopaedic Association (BOA), and New Zealand Orthopaedic Association (NZOA) suggest postoperative antibiotic administration for a duration of no more than 24-36 hours postoperatively.

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  • Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
  • Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
  • Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
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OrthoEvidence. COA 2015: No high-level evidence support for postoperative antibiotic prophylaxis in TJA. ACE Report. 2015;5(6):65. Available from: https://myorthoevidence.com/AceReport/Report/

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